Triethylamine → HCID 178478382, compound

HRID 2264384Notes

Reaction equation

HRID 2264384 reaction equation
[Cl:1][CH:2]1[N:11]=[C:10](Cl)[C:9]2[CH2:8][CH2:7][CH2:6][CH2:5][C:4]=2[NH:3]1.[NH2:13][C:14]1[CH:18]=[C:17]([CH:19]2[CH2:21][CH2:20]2)[NH:16][N:15]=1.C(N(CC)CC)C>C(O)C>[Cl:1][CH:2]1[N:11]=[C:10]([NH:13][C:14]2[NH:15][N:16]=[C:17]([CH:19]3[CH2:21][CH2:20]3)[CH:18]=2)[C:9]2[CH2:8][CH2:7][CH2:6][CH2:5][C:4]=2[NH:3]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 27580143-cyclopropyl-1H-pyrazol-5-amineHCID 68521080HCID 68521080, compound

Product 1

HCID 178478382HCID 178478382, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
120 °C

Procedure

2,4-Dichloro-1,2,5,6,7,8-hexahydro-quinazoline (1 g, 4.93 mmol) and 3-amino-5-cyclopropylpyrazole (0.606 g, 4.93 mmol) in ethanol (8 ml) was treated with triethylamine (1.24 ml, 8.87 mmol) and the mixture heated at 120° C. for 3 days, cooled and filtered to give (0.72 g, 51%) as a colourless solid.

Workup

  1. temperaturecooled
  2. filtrationfiltered
  3. customto give (0.72 g, 51%) as a colourless solid

Sources & evidence

ORD record
ord-b6f50a9f5af0470e933f4cdd969b9969
Source dataset
uspto-grants-2010_12
Patent number
US07855214B2

Reaction notes

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