Hydrochloric Acid → HCID 68781860, compound

HRID 2264430Notes

Reaction equation

HRID 2264430 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[N:20]=[C:19]([O:21][CH3:22])[CH:18]=[C:17]([O:23][CH3:24])[N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:25]>C(O)C.O1CCOCC1>[ClH:25].[ClH:25].[CH3:22][O:21][C:19]1[CH:18]=[C:17]([O:23][CH3:24])[N:16]=[C:15]([NH:14][CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[N:20]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 68779241HCID 68779241, compound

Product 1

HCID 68781860HCID 68781860, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of 4-(4,6-dimethoxy-pyrimidin-2-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (1.97 g, 5.82 mmol) in ethanol (50 mL) and 4 M HCl in dioxane (75 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 239.1 [M+H]+.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe crude product used in the consecutive step without further purification

Sources & evidence

ORD record
ord-6266544659a0465c9a6726e3b882e4bd
Source dataset
uspto-grants-2010_12
Patent number
US07855194B2

Reaction notes

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