Hydrochloric Acid → HCID 86615297, compound

HRID 2264451Notes

Reaction equation

HRID 2264451 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[N:24]=[C:23]([NH2:25])[C:22]3[CH:21]=[C:20]4[O:26][CH2:27][O:28][C:19]4=[CH:18][C:17]=3[N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:29]>C(O)C.O1CCOCC1>[ClH:29].[ClH:29].[NH:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[N:24]=[C:23]([NH2:25])[C:22]3[CH:21]=[C:20]4[O:26][CH2:27][O:28][C:19]4=[CH:18][C:17]=3[N:16]=2)[CH2:10][CH2:9]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 68778514HCID 68778514, compound

Product 1

HCID 86615297HCID 86615297, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of 4-(8-amino-[1,3]dioxolo[4,5-g]quinazolin-6-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (0.6 g, 1.55 mmol) in ethanol (5 mL) and 4 M HCl in dioxane (20 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ESI): 288.4 [M+H]+.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe crude product used in the consecutive step without further purification

Sources & evidence

ORD record
ord-9a90f340789147d38de4b9f403a02915
Source dataset
uspto-grants-2010_12
Patent number
US07855194B2

Reaction notes

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