反应详情

A solution of 7.83 g (30.4 mMol) of 6-chloro-4-(quinolin-6-yloxy)-pyrimidine (step 1.1) and 121 ml of a 1 N MeNH2 in THF is stirred for 7.5 h in a sealed vessel. After addition of 30 g of SiO2, the mixture is concentrated and the resulting powder put on top of a chromatograph column (SiO2; EtOAc). Eluation (EtOAc→EtOAc/EtOH 50:1→20:1→9:1) gives the title compound: m.p.: 173° C.; MS: [M+1]+=253; Anal.: C,H,N.

1. concentrationthe mixture is concentrated