反应详情

A solution of 134 mg (0.27 mMol) 5-(6-chloro-pyrimidin-4-yloxy)-2,3-dihydro-indole-1-carboxylic acid [4-(4-ethyl-piperazin-1-ylmethyl)-phenyl]-amide in 5 ml THF and 1.2 ml methylamin solution (2 M in THF) is stirred for 3 d in a sealed tube at rt. The reaction mixture is concentrated and the residue chromatographed by reversed phase MPLC (Gilson system), yielding the title compound: MS: [M+1]+=488; HPLC: BtRet=11.5.

1. concentrationThe reaction mixture is concentrated
2. customthe residue chromatographed by reversed phase MPLC (Gilson system)