Dimethylamine → HCID 59596854, compound

HRID 2264652Notes

Reaction equation

HRID 2264652 reaction equation
C[O:2][C:3](=O)[CH:4]([NH:11][CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([F:28])[CH:23]=2)=[C:16]([O:29][CH3:30])[CH:15]=1)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[CH3:32][NH:33][CH3:34].C[Al](C)C>O1CCCC1.CCCCCCC>[F:28][C:24]1[CH:23]=[C:22]([CH:27]=[CH:26][CH:25]=1)[CH2:21][O:20][C:17]1[CH:18]=[CH:19][C:14]([CH2:13][CH2:12][NH:11][CH:4]([C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=2)[C:3]([N:33]([CH3:34])[CH3:32])=[O:2])=[CH:15][C:16]=1[O:29][CH3:30]

Participants

6

Reactant 3

HCID 674DimethylamineHCID 16682925TrimethylaluminumHCID 59596844HCID 59596844, compound

Product 1

HCID 59596854HCID 59596854, compoundYield 52%

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 8900HeptaneSolvent

Procedure

This compound was synthesized according to the procedure described in Scheme 6, step B, using 115 mg of 2-[2-[4-(3-fluoro-benzyloxy)-3-methoxy-phenyl]-ethylamino]-2-phenyl-acetic acid methyl ester (0.27 mmol), 1.06 ml (2.1 mmol) of a 2 M solution of dimethylamine in tetrahydrofuran and 0.53 ml (1.06 mmol) of a 2 M solution of trimethyl aluminium in heptane. 66 mg (52% yield) of the title compound were isolated as a white solid.

Workup

  1. customThis compound was synthesized

Sources & evidence

ORD record
ord-5aea36bbf91d4121b08cd08cdc6b8497
Source dataset
uspto-grants-2010_12
Patent number
US07855227B2

Reaction notes

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