Hydrochloric Acid → Hydrochloric Acid

HRID 2264889Notes

Reaction equation

HRID 2264889 reaction equation
C(OC([NH:8][CH2:9][C:10]([N:12]1[CH2:24][CH2:23][C:22]2[C:21]3[C:16](=[CH:17][CH:18]=[C:19]([CH3:25])[CH:20]=3)[NH:15][C:14]=2[CH:13]1[C:26]1[CH:27]=[C:28]([OH:32])[CH:29]=[CH:30][CH:31]=1)=[O:11])=O)(C)(C)C.[ClH:33].O1CCOCC1>>[NH2:8][CH2:9][C:10]([N:12]1[CH2:24][CH2:23][C:22]2[C:21]3[C:16](=[CH:17][CH:18]=[C:19]([CH3:25])[CH:20]=3)[NH:15][C:14]=2[CH:13]1[C:26]1[CH:27]=[C:28]([OH:32])[CH:29]=[CH:30][CH:31]=1)=[O:11].[ClH:33]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 59597144HCID 59597144, compound

Product 2

HCID 313Hydrochloric AcidHCID 46225271HCID 46225271, compound

Procedure

(tert-Butoxy)-N-{2-[1-(3-hydroxyphenyl)-6-methyl-(1,2,3,4-tetrahydro-beta-carbolin-2-yl)]-2-oxoethyl}carboxamide 11 was treated with HCl in dioxane (4 N, 10 equiv) for 30 min, and the solvent was removed to give 3-(2-glycyl-6-methyl-2,3,4,9-tetrahydro-1H-beta-carbolin-1-yl)phenol 14 as its HCl salt.

Workup

  1. customthe solvent was removed

Sources & evidence

ORD record
ord-03cae3a3fa1f424cb23e10d2e885a45f
Source dataset
uspto-grants-2010_12
Patent number
US07855295B2

Reaction notes

Loading…