Hydrochloric Acid → HCID 11337670, compound

HRID 2264891Notes

Reaction equation

HRID 2264891 reaction equation
C(OC([NH:8][CH2:9][CH2:10][C:11]([N:13]1[CH2:25][CH2:24][C:23]2[C:22]3[C:17](=[CH:18][CH:19]=[C:20]([Cl:26])[CH:21]=3)[NH:16][C:15]=2[CH:14]1[C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([OH:33])[CH:28]=1)=[O:12])=O)(C)(C)C.Cl.O1CCOCC1>>[NH2:8][CH2:9][CH2:10][C:11]([N:13]1[CH2:25][CH2:24][C:23]2[C:22]3[C:17](=[CH:18][CH:19]=[C:20]([Cl:26])[CH:21]=3)[NH:16][C:15]=2[CH:14]1[C:27]1[CH:28]=[C:29]([OH:33])[CH:30]=[CH:31][CH:32]=1)=[O:12]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 59597095HCID 59597095, compound

Product 1

HCID 11337670HCID 11337670, compound

Procedure

(tert-Butoxy)-N-{3-[1-(3-hydroxyphenyl)-6-chloro-(1,2,3,4-tetrahydro-beta-carbolin-2-yl)]-3-oxopropyl}carboxamide was treated with HCl in dioxane (4 N, 10 equiv) for 30 min, and the solvent was removed to give a residue which was purified to yield 3-(2-beta-alanyl-6-chloro-2,3,4,9-tetrahydro-1H-beta-carbolin-1-yl)phenol 23.

Workup

  1. customthe solvent was removed
  2. customto give a residue which
  3. customwas purified

Sources & evidence

ORD record
ord-caa422c600144d49ae193482d3cbfdf3
Source dataset
uspto-grants-2010_12
Patent number
US07855295B2

Reaction notes

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