Ethanol → HCID 131728596, compound

HRID 2265141Notes

Reaction equation

HRID 2265141 reaction equation
[C:1]1([CH3:14])[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C@@H:7]1[CH2:12][CH2:11][NH:10][CH2:9][C@H:8]1[OH:13].C1(C)[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[C@H:21]1[CH2:26][CH2:25][NH:24]C[C@@H]1O.[C:29]([OH:38])(=[O:37])[C@@H:30]([C@H:32]([C:34]([OH:36])=[O:35])[OH:33])[OH:31].[CH2:39]([OH:41])[CH3:40]>>[C:34]([C@@H:32]([C@H:30]([C:29]([OH:38])=[O:37])[OH:31])[OH:33])([OH:36])=[O:35].[OH:13][C@@H:8]1[C@@H:7]([C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][C:1]=2[CH3:14])[CH2:12][CH2:11][N:10]([CH2:29][C@H:25]2[CH2:24][C@H:39]([OH:41])[C:40]3=[N:20][CH:19]=[CH:18][CH:17]=[C:16]3[CH2:21][CH2:26]2)[CH2:9]1

Participants

5

Reactant 4

HCID 702EthanolHCID 444305L-Tartaric acidHCID 68427262HCID 68427262, compoundHCID 68427575HCID 68427575, compound

Product 1

HCID 131728596HCID 131728596, compound

Procedure

A free amine form of the entitled compound was obtained in the same manner as in Example 15, for which, however, (3R*,4R*)-4-o-tolyl-piperidin-3-ol obtained in Production Example 12 were used in place of (3S*,4S*)-4-o-tolyl-piperidin-3-ol used in Example 15. The obtained free amine compound and the same amount of L-tartaric acid were mixed in ethanol, and crystallized from heptane added thereto to obtain the entitled compound as a white solid.

Workup

  1. customcrystallized from heptane
  2. additionadded

Sources & evidence

ORD record
ord-4ce0392fe6b54029a3fd70e0b4596c40
Source dataset
uspto-grants-2010_12
Patent number
US07855294B2

Reaction notes

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