Hydrochloric Acid → HCID 57470865, compound

To a solution of 3-(azetidin-1-yl)-1-benzhydrylazetidine (643 mg) in ethyl acetate was added a 4N solution of hydrochloric acid in ethyl acetate (1.16 ml), followed by concentration. The resultant residue was dissolved in methanol (65 ml), and 20% palladium hydroxide (811 mg) was added thereto. This was stirred at room temperature under a pressurized hydrogen atmosphere (0.3 to 0.4 MPa) for 4 hr. The catalyst was removed by filtration, and the filtrate was concentrated. Hexane was added to the residue to suspend a solid. The residue after removing a supernatant by a pipette was concentrated under reduced pressure to provide a crude product of the titled compound as a pale yellow oil (471.2 mg).

1. concentrationfollowed by concentration
2. dissolutionThe resultant residue was dissolved in methanol (65 ml)
3. addition20% palladium hydroxide (811 mg) was added
4. customThe catalyst was removed by filtration
5. concentrationthe filtrate was concentrated
6. additionHexane was added to the residue
7. customThe residue after removing a supernatant by a pipette
8. concentrationwas concentrated under reduced pressure

ORD record

ord-d9b625cbcb684918a3cfcc6bd2262d3a

Source dataset

uspto-grants-2010_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07855290B2