Piperazine → HCID 178480644, compound

HRID 2265846Notes

Reaction equation

HRID 2265846 reaction equation
C1(N2C(=O)C3=CNC4C=C[C:16]([N:19]5[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]5)=NC=4C3=N2)C=CC=CC=1.F[C:28]1[CH:37]=[CH:36][C:35]2[NH:34][CH:33]=[C:32]3[C:38](=[O:47])[N:39]([C:41]4[CH:46]=[CH:45][CH:44]=[CH:43][N:42]=4)[N:40]=[C:31]3[C:30]=2[N:29]=1.CN1CCNCC1.N1CCNCC1>>[CH3:16][N:19]1[CH2:24][CH2:23][N:22]([C:28]2[CH:37]=[CH:36][C:35]3[NH:34][CH:33]=[C:32]4[C:38](=[O:47])[N:39]([C:41]5[CH:46]=[CH:45][CH:44]=[CH:43][N:42]=5)[N:40]=[C:31]4[C:30]=3[N:29]=2)[CH2:21][CH2:20]1

Participants

5

Reactant 4

HCID 4837PiperazineHCID 531671-MethylpiperazineHCID 178515200HCID 178515200, compoundHCID 178515211HCID 178515211, compound

Product 1

HCID 178480644HCID 178480644, compound

Procedure

The title compound was prepared following the procedure described for 6a using 5b and 1-methylpiperazine instead of 5a and piperazine respectively. 1H-NMR (DMSO-d6) δ (ppm): 2.55 (4H, br), 2.77 (3H, brs), 3.80 (4H, br), 7.20 (1H, m), 7.27 (6H, d, J=9.24 Hz), 7.87 (2H, m), 8.20 (1H, d, J=8.24 Hz), 8.48 (1H, m), 8.60 (1H, s). m/z 362.4 (MH+).

Sources & evidence

ORD record
ord-1b9519afeaeb4029b8e6b4d5e76d2d38
Source dataset
uspto-grants-2010_12
Patent number
US07858614B2

Reaction notes

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