Piperazine → HCID 178429873, compound

HRID 2265849Notes

Reaction equation

HRID 2265849 reaction equation
C1(N2C(=O)C3=CNC4C=CC(N5CCNCC5)=NC=4C3=N2)C=CC=CC=1.F[C:28]1[CH:37]=[CH:36][C:35]2[NH:34][CH:33]=[C:32]3[C:38](=[O:47])[N:39]([C:41]4[CH:46]=[CH:45][CH:44]=[CH:43][N:42]=4)[N:40]=[C:31]3[C:30]=2[N:29]=1.[CH3:48][CH:49]1[CH2:54][NH:53][CH2:52][CH2:51][NH:50]1.N1CCNCC1>>[CH3:48][CH:49]1[NH:50][CH2:51][CH2:52][N:53]([C:28]2[CH:37]=[CH:36][C:35]3[NH:34][CH:33]=[C:32]4[C:38](=[O:47])[N:39]([C:41]5[CH:46]=[CH:45][CH:44]=[CH:43][N:42]=5)[N:40]=[C:31]4[C:30]=3[N:29]=2)[CH2:54]1

Participants

5

Reactant 4

HCID 4837PiperazineHCID 660572-MethylpiperazineHCID 178515200HCID 178515200, compoundHCID 178515211HCID 178515211, compound

Product 1

HCID 178429873HCID 178429873, compound

Procedure

The title compound was prepared following the procedure described for 6a using 5b and 2-methylpiperazine instead of 5a and piperazine respectively. 1H-NMR (DMSO-d6) δ (ppm): 1.07 (3H, d, J=6.87 Hz), 2.78 (3H, m), 3.00 (2H, m), 4.31 (2H, m), 7.14 (2H, m), 7.83 (2H, m), 8.22 (1H, dt, J=7.96, 7.64 Hz), 8.49 (2H, m). m/z 362.4 (MH+).

Sources & evidence

ORD record
ord-e7d8854673f64de99a0890df3f76d1ca
Source dataset
uspto-grants-2010_12
Patent number
US07858614B2

Reaction notes

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