Piperazine → HCID 178492065, compound

HRID 2265852Notes

Reaction equation

HRID 2265852 reaction equation
C1(N2C(=O)C3=CNC4C=C[C:16]([N:19]5[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]5)=NC=4C3=N2)C=CC=CC=1.F[C:28]1[CH:37]=[CH:36][C:35]2[NH:34][CH:33]=[C:32]3[C:38](=[O:49])[N:39]([C:41]4[CH:46]=[CH:45][C:44]([O:47][CH3:48])=[CH:43][CH:42]=4)[N:40]=[C:31]3[C:30]=2[N:29]=1.CN1CCNCC1.N1CCNCC1>>[CH3:48][O:47][C:44]1[CH:45]=[CH:46][C:41]([N:39]2[C:38](=[O:49])[C:32]3=[CH:33][NH:34][C:35]4[CH:36]=[CH:37][C:28]([N:22]5[CH2:23][CH2:24][N:19]([CH3:16])[CH2:20][CH2:21]5)=[N:29][C:30]=4[C:31]3=[N:40]2)=[CH:42][CH:43]=1

Participants

5

Reactant 4

HCID 4837PiperazineHCID 531671-MethylpiperazineHCID 178492064HCID 178492064, compoundHCID 178515211HCID 178515211, compound

Product 1

HCID 178492065HCID 178492065, compound

Procedure

The title compound was prepared following the procedure described for 6a using 5c and 1-methylpiperazine instead of 5a and piperazine respectively. 1H-NMR (DMSO-d6) δ (ppm): 2.22 (3H, s), 2.56 (4H, m), 3.64 (4H, m), 6.98 (2H, d, J=9.07 Hz), 7.15 (1H, d, J=9.34 Hz), 7.78 (6H, d, J=9.34 Hz), 8.10 (2H, d, J=9.07 Hz), 8.45 (1H, s). m/z 391.4 (MH+).

Sources & evidence

ORD record
ord-1d9171f0b0034ab3833b78d11c79955f
Source dataset
uspto-grants-2010_12
Patent number
US07858614B2

Reaction notes

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