huagongshe.com
HRID2265937

反应详情

EQUATION

反应方程式

HRID 2265937 的结构方程式

REACTANTS

反应物

3
结构：CN1CCCC1=O
HCID13387

N-Methyl-2-pyrrolidone

C5H9NO

结构：CS(=O)(=O)Nc1ccc(CN)cc1F.Cl
HCID21097525

未命名化合物

结构：CC(C)(C)c1cc(C(F)(F)F)c(C=CC(=O)O)cn1
HCID68784901

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)c1cc(C(F)(F)F)c(C=CC(=O)NCc2ccc(NS(C)(=O)=O)c(F)c2)cn1
HCID68782151

未命名化合物

收率 62.7%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

3-Fluoro-4-methanesulfonylaminobenzylamine hydrochloride (41.2 mg, 0.162 mmol) was reacted with 3-(6-tert-butyl-4-trifluoromethyl-pyridin-3-yl)-acrylic acid (1.0 eq, 44.2 mg) DMTMM (1.0 eq, 44.8 mg) and NMP (1.2 eq, 22 μl) in THF to give the title compound (48 mg, 62.6%) after purification by column chromatography (Hex/EtOAc=1/1).