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HRID2265938

反应详情

EQUATION

反应方程式

HRID 2265938 的结构方程式

REACTANTS

反应物

3
结构：CN1CCCC1=O
HCID13387

N-Methyl-2-pyrrolidone

C5H9NO

结构：CC(C)(C)c1cc(C(F)(F)F)c(C=CC(=O)O)cn1
HCID68784901

未命名化合物

结构：C#Cc1cc(CN)cc(F)c1NS(C)(=O)=O.Cl
HCID86625519

未命名化合物

PRODUCTS

生成物

1
结构：C#Cc1cc(CNC(=O)C=Cc2cnc(C(C)(C)C)cc2C(F)(F)F)cc(F)c1NS(C)(=O)=O
HCID74332388

未命名化合物

收率 30.2%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

N-(4-Aminomethyl-2-ethynyl-6-fluoro-phenyl)-methanesulfonamide HCl salt (11.2 mg, 0.04 mmol) was reacted with 3-(6-tert-butyl-4-trifluoromethyl-pyridin-3-yl)-acrylic acid (1.0 eq, 11.0 mg) DMTMM (1.0 eq, 11.1 mg) and NMP (1.2 eq, 6 μl) in THF to give the title compound (6 mg, 30.2%) after purification by column chromatography (Hex/EtOAc=3/2).