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HRID2265953

反应详情

EQUATION

反应方程式

HRID 2265953 的结构方程式

REACTANTS

反应物

3
结构：CN1CCCC1=O
HCID13387

N-Methyl-2-pyrrolidone

C5H9NO

结构：CS(=O)(=O)Nc1ccc(CN)cc1F.Cl
HCID21097525

未命名化合物

结构：CC(C)(C)c1ccc(C=CC(=O)O)c(Br)n1
HCID86625523

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)c1ccc(C=CC(=O)NCc2ccc(NS(C)(=O)=O)c(F)c2)c(Br)n1
HCID74332390

未命名化合物

收率 32.8%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

3-Fluoro-4-methanesulfonylaminobenzylamine hydrochloride (116 mg, 0.454 mmol) was reacted with 3-(2-bromo-6-tert-butyl-pyridin-3-yl)-acrylic acid (1.0 eq, 129 mg) DMTMM (1.0 eq, 126 mg) and NMP (1.2 eq, 60 μl) in THF to give the title compound (72 mg, 32.8%) after purification by column chromatography (Hex/EtOAc=1/1).