Lithium Hydroxide → 3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-acrylic acid

HRID 2265960Notes

Reaction equation

C[O:2][C:3](=[O:17])[CH:4]=[CH:5][C:6]1[C:7]([Cl:16])=[N:8][C:9]([C:12]([F:15])([F:14])[F:13])=[CH:10][CH:11]=1.[Li+].[OH-]>>[Cl:16][C:7]1[C:6]([CH:5]=[CH:4][C:3]([OH:17])=[O:2])=[CH:11][CH:10]=[C:9]([C:12]([F:13])([F:14])[F:15])[N:8]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 86625525HCID 86625525, compound

Product 1

HCID 723356323-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-acrylic acidYield 99.8%

Procedure

3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-acrylic acid methyl ester (200 mg, 0.753 mmol) was reacted with 0.5N-LiOH (2 eq) to give 3-(2-chloro-6-trifluoromethyl-pyridin-3-yl)-acrylic acid (189 mg, 99%).

Sources & evidence

ORD record: ord-bbf8297716024f8fb9dc331e48c298be
Source dataset: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07858621B2

Reaction notes

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