反应详情

A mixture of [2-difluoromethoxy-8-fluoro-3-(4-fluorobenzyl)-4-methylquinolin-5-yloxy]acetic acid methyl ester (0.20 g), tetrahydrofuran (4.0 mL), methanol (4.0 mL), water (3.0 mL) and lithium hydroxide (0.020 g) was stirred at room temperature for 40 minutes. The mixture was partitioned between ethyl acetate and 1.0 M aqueous hydrochloric acid. The aqueous phase was extracted with ethyl acetate and the combined organic phases were dried over sodium sulfate and the solvent removed under reduced pressure. Purification of the residue by preparative reverse-phase HPLC using a gradient over 30 minutes of acetonitrile in water gave title compound as a white solid, 0.10 g.

1. customThe mixture was partitioned between ethyl acetate and 1.0 M aqueous hydrochloric acid
2. extractionThe aqueous phase was extracted with ethyl acetate
3. dry with materialthe combined organic phases were dried over sodium sulfate
4. customthe solvent removed under reduced pressure
5. customPurification of the residue by preparative reverse-phase
6. customover 30 minutes