Hydrochloric Acid → 1-(2,6-Dichloro-3-fluorophenyl)ethyl acetate
Reaction equation
Cl.[Cl:2][C:3]1[C:8]([F:9])=[CH:7][CH:6]=[C:5]([Cl:10])[C:4]=1[CH:11]([OH:13])[CH3:12].[CH2:14]([OH:16])[CH3:15]>[Fe]>[C:14]([O:13][CH:11]([C:4]1[C:5]([Cl:10])=[CH:6][CH:7]=[C:8]([F:9])[C:3]=1[Cl:2])[CH3:12])(=[O:16])[CH3:15]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 85 °C
Procedure
2 M HCl (0.2 mL) is added to solution of compound A1 (0.97 mmol) in 2 mL of ethanol. The mixture is then put in an ice bath and Fe powder (365 mg) is added slowly. The reaction is heated to 85° C. for 1 hr and cooled to room temperature. Celite (0.5 g) is added to stir and the resulting mixture is filtered through a bed of celite and rinsed with ethanol. The filtrated is evaporated to give a brown oil residue, compound A2. The residue is used without further purification.
Workup
- customThe mixture is then put in an ice bath
- temperaturecooled to room temperature
- additionCelite (0.5 g) is added
- filtrationthe resulting mixture is filtered through a bed of celite and
- washrinsed with ethanol
- customThe filtrated is evaporated
Sources & evidence
- ORD record
- ord-329d7e5d6edc4f00a6c864bdaeb39899
- Source dataset
- uspto-grants-2010_12
- Patent number
- US07858643B2
Reaction notes
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