Trifluoroacetic acid → HCID 57877632, compound

HRID 2266754Notes

Reaction equation

HRID 2266754 reaction equation
[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][C:14]([C:20]2[CH:29]=[CH:28][C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[CH:21]=2)([C:17](O)=[O:18])[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>ClCCl>[CH:17]([C:14]1([C:20]2[CH:29]=[CH:28][C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[CH:21]=2)[CH2:13][CH2:12][N:11]([C:9]([O:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[O:10])[CH2:16][CH2:15]1)=[O:18]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68440684HCID 68440684, compound

Product 1

HCID 57877632HCID 57877632, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1-[(Benzyloxy)carbonyl]-4-(2-naphthyl)piperidine-4-carboxylic acid To a solution of 1.60 g (3.59 mmol) of Intermediate 9 in 10 mL of anhydrous dichloromethane was added 10 mL of trifluoroacetic acid. The resulting mixture was stirred at ambient temperature for 2 h and then all volatiles were removed in vacuo. The resulting residue was dissolved in 15 mL of anhydrous toluene and all volatiles were again removed in vacuo to afford the title compound as a white solid. LC/MS 390.2 (M+1).

Workup

  1. customall volatiles were removed in vacuo
  2. dissolutionThe resulting residue was dissolved in 15 mL of anhydrous toluene
  3. customall volatiles were again removed in vacuo

Sources & evidence

ORD record
ord-a1ffca7bce8e489dbfe50eb6ba052651
Source dataset
uspto-grants-2010_12
Patent number
US07858629B2

Reaction notes

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