反应详情

温度

120 °C

A mixture of 4,6-dichloropyrimidine (0.25 g, 1.7 mmol), isobutyl piperazine-1-carboxylate (0.31 g, 1.7 mmol), triethylamine (0.23 mL, 1.8 mmol), and DMF (4.2 mL) was sealed in a microwave reactor vial and heated by microwave irradiation at 120° C. for 2 minutes. The reaction was cooled, diluted with water, and extracted with CH2Cl2. The combined extracts were dried over Na2SO4 and evaporated to obtain isobutyl 4-(6-chloropyrimidin-4-yl)piperazine-1-carboxylate. LC/MS: m/z 299.2 (M+H)+ at 3.10 min (10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA)).

1. customwas sealed in a microwave reactor vial
2. temperatureThe reaction was cooled
3. extractionextracted with CH2Cl2
4. dry with materialThe combined extracts were dried over Na2SO4
5. customevaporated