Hydrochloric Acid → HCID 68429818, compound

HRID 2267172Notes

Reaction equation

HRID 2267172 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[C:13]([CH3:14])=[C:12]([N:15]2[CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][C:16]2=[O:28])[N:11]=[N:10]1>O1CCOCC1>[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[C:13]([CH3:14])=[C:12]([N:15]2[CH2:20][CH2:19][NH:18][CH2:17][C:16]2=[O:28])[N:11]=[N:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58945812HCID 58945812, compound

Product 1

HCID 68429818HCID 68429818, compoundYield 98.5%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

4N Hydrochloric acid solution in dioxane (10 ml) was added to 150 mg of tert-butyl 4-[1-(2-chlorophenyl)-5-methyl-1H-[1,2,3]-triazol-4-yl]-3-oxopiperazine-1-carboxylate prepared in Example 26, the mixture was stirred at room temperature for 3 hours and the solvent was evaporated in vacuo to give 110 mg of the title compound as a white solid.

Workup

  1. customthe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-3fae91e3f7ca4c129c68464194063c8f
Source dataset
uspto-grants-2010_12
Patent number
US07858800B2

Reaction notes

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