Lithium Hydroxide → HCID 57807494, compound

HRID 2267262Notes

Reaction equation

[NH2:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][C:5]([CH2:12][C@@H:13]([O:34][C:35]([N:37]2[CH2:42][CH2:41][CH:40]([N:43]3[CH2:49][CH2:48][C:47]4[CH:50]=[CH:51][CH:52]=[CH:53][C:46]=4[NH:45][C:44]3=[O:54])[CH2:39][CH2:38]2)=[O:36])[C:14]([N:16]2[CH2:21][CH2:20][N:19]([CH:22]3[CH2:27][CH2:26][N:25]([CH3:28])[CH2:24][CH2:23]3)[CH2:18][C@H:17]2[C:29]([O:31]CC)=[O:30])=[O:15])=[CH:4][C:3]=1[Cl:55].[Li+].[OH-]>>[NH2:1][C:2]1[C:7]([C:8]([F:9])([F:11])[F:10])=[CH:6][C:5]([CH2:12][C@@H:13]([O:34][C:35]([N:37]2[CH2:38][CH2:39][CH:40]([N:43]3[CH2:49][CH2:48][C:47]4[CH:50]=[CH:51][CH:52]=[CH:53][C:46]=4[NH:45][C:44]3=[O:54])[CH2:41][CH2:42]2)=[O:36])[C:14]([N:16]2[CH2:21][CH2:20][N:19]([CH:22]3[CH2:23][CH2:24][N:25]([CH3:28])[CH2:26][CH2:27]3)[CH2:18][C@H:17]2[C:29]([OH:31])=[O:30])=[O:15])=[CH:4][C:3]=1[Cl:55]

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 57807404HCID 57807404, compound

Product 1

HCID 57807494HCID 57807494, compound

Procedure

Prepared analogously to Example 22.1 from 80.0 mg (0.10 mmol) ethyl(S)-1-{(R)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carbonyloxy]-propionyl}-4-(1-methyl-piperidin-4-yl)-piperazine-2-carboxylate and 0.46 mL (0.23 mmol) 0.5 M LiOH solution.

Sources & evidence

ORD record: ord-8ae7243ab6044c9eb497878e9fd713e7
Source dataset: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07858622B2

Reaction notes

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