Hydrochloric Acid → HCID 60204495, compound

HRID 2267371Notes

Reaction equation

HRID 2267371 reaction equation
[Cl:1][C:2]1[S:6][C:5]([C:7]2[C:12]([C:13]3[CH:14]=[C:15]([NH:19][C:20](=[O:31])[CH2:21][N:22](C)[C:23](=O)OC(C)(C)C)[CH:16]=[CH:17][CH:18]=3)=[CH:11][N:10]=[C:9]([NH:32][CH2:33][CH2:34][N:35]3[C:39]([CH3:41])([CH3:40])[C:38](=[O:42])[NH:37][C:36]3=[O:43])[N:8]=2)=[CH:4][CH:3]=1.Cl>O1CCOCC1>[Cl:1][C:2]1[S:6][C:5]([C:7]2[C:12]([C:13]3[CH:14]=[C:15]([NH:19][C:20](=[O:31])[CH2:21][NH:22][CH3:23])[CH:16]=[CH:17][CH:18]=3)=[CH:11][N:10]=[C:9]([NH:32][CH2:33][CH2:34][N:35]3[C:39]([CH3:41])([CH3:40])[C:38](=[O:42])[NH:37][C:36]3=[O:43])[N:8]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 60204494HCID 60204494, compound

Product 1

HCID 60204495HCID 60204495, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A solution of 15 mg (0.024 mmol) of tert-Butyl 2-(3-{4-(5-chlorothiophen-2-yl)-2-[2-(5,5-dimethyl-2,4-dioxoimidazolidin-1-yl)ethylamino]pyrimidin-5-yl}phenylamino)-2-oxoethyl(methyl)carbamate in 1 mL of 1,4-dioxane was treated with 2 mL of a 4 M solution of HCl in 1,4-dioxane and stirred 1 h at rt, then concentrated in vacuo to give the desired product as the hydrochloride salt. MS (M+H)+ 528.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-d7b64e7b3d994239b834f5d51d5a4b90
Source dataset
uspto-grants-2010_12
Patent number
US07858785B2

Reaction notes

Loading…