Cesium carbonate → 5-phenyl-1H-indole-7-carboxylic acid

To a solution of 5-bromo-1H-indole-7-carboxylic acid (10 g, 41.8 mmol) in dioxane (150 mL) and water (50 mL) was added phenylboronic acid (19.5 g, 159.9 mmol), cesium carbonate (26.0 g, 79.8 mmol), 1,3-Bis(2,4,6-trimethylphenyl) imidazolium chloride (2.8 g, 8.2 mmol), and palladiumacetate (0.9 g, 4.01 mmol). The reaction mixture was stirred at ambient temperature for 15 min, and then was refluxed at 80° C. for 15 hr. The organic solvent was removed under reduced pressure and the water layer was adjusted to pH=1-2 with 6 M hydrochloric acid before ethyl acetate (350 mL) was added into it. The organic layer washed with water (100 mL×3), dried and concentrated at 45° C. to a thick oil (approximately 40 mL solvent left), cooled to −20° C., and filtered. The solid was washed with cold ethyl acetate (10 mL×3), and collected. The filtrate was concentrated to a thick oil at 45° C., then was cooled to −20° C., and off-white solid was obtained. The suspension was filtered and washed with cold ethyl acetate (5 mL×3). The filtrate was discard after 3 iterations of the above procedure.

1. temperaturewas refluxed at 80° C. for 15 hr
2. customThe organic solvent was removed under reduced pressure
3. additionwas added into it
4. washThe organic layer washed with water (100 mL×3)
5. customdried
6. concentrationconcentrated at 45° C. to a thick oil (approximately 40 mL solvent left)
7. temperaturecooled to −20° C.
8. filtrationfiltered
9. washThe solid was washed with cold ethyl acetate (10 mL×3)
10. customcollected
11. concentrationThe filtrate was concentrated to a thick oil at 45° C.
12. temperaturewas cooled to −20° C.
13. customoff-white solid was obtained
14. filtrationThe suspension was filtered
15. washwashed with cold ethyl acetate (5 mL×3)

ORD record

ord-4aaf1123c6fc4b40b87f539300a8529b

Source dataset

uspto-grants-2010_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07858796B2