Sodium Iodide → HCID 59003317, compound

HRID 2267559Notes

Reaction equation

HRID 2267559 reaction equation
Cl[CH2:2][CH2:3][CH2:4][S:5]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[C:22]3[C:17](=[C:18]([C:29]([NH2:31])=[O:30])[CH:19]=[C:20]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[CH:21]=3)[NH:16][CH:15]=2)[CH2:10][CH2:9]1)(=[O:7])=[O:6].[CH:32]1([CH2:36][OH:37])[CH2:35][CH2:34][CH2:33]1.C([O-])([O-])=O.[K+].[K+].[I-].[Na+]>>[CH:32]1([CH2:36][O:37][CH2:2][CH2:3][CH2:4][S:5]([N:8]2[CH2:13][CH2:12][CH:11]([C:14]3[C:22]4[C:17](=[C:18]([C:29]([NH2:31])=[O:30])[CH:19]=[C:20]([C:23]5[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=5)[CH:21]=4)[NH:16][CH:15]=3)[CH2:10][CH2:9]2)(=[O:7])=[O:6])[CH2:35][CH2:34][CH2:33]1

Participants

5

Reactant 4

HCID 5238Sodium IodideHCID 11430Potassium CarbonateHCID 78130CyclobutylcarbinolHCID 590032803-{1-[(3-chloropropyl)sulfonyl]-4-piperidinyl}-5-phenyl-1H-indole-7-carboxamide

Product 1

HCID 59003317HCID 59003317, compoundYield 12.6%

Procedure

Following the general procedure of example 159, 3-{1-[(3-chloropropyl)sulfonyl]-4-piperidinyl}-5-phenyl-1H-indole-7-carboxamide (40.0 mg, 0.087 mmol), cyclobutylmethanol (86 mg, 0.87 mmol), K2CO3 (35.0 mg, 0.35 mmol) and sodium iodide (0.5 mg) were reacted to give the title compound (5.6 mg, 12.6%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-67bd1d349a7042bcbdaa67484913cfe4
Source dataset
uspto-grants-2010_12
Patent number
US07858796B2

Reaction notes

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