Triethylamine → HCID 59003295, compound

HRID 2267579Notes

Reaction equation

HRID 2267579 reaction equation
[C:1]1([C:7]2[CH:8]=[C:9]3[C:13](=[C:14]([C:16]([NH2:18])=[O:17])[CH:15]=2)[NH:12][CH:11]=[C:10]3[CH:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[O:25]1[CH:29]=[CH:28][C:27]([C:30]2[S:34][CH:33]=[C:32]([S:35](Cl)(=[O:37])=[O:36])[CH:31]=2)=[N:26]1.C(N(CC)CC)C>>[O:25]1[CH:29]=[CH:28][C:27]([C:30]2[S:34][CH:33]=[C:32]([S:35]([N:22]3[CH2:23][CH2:24][CH:19]([C:10]4[C:9]5[C:13](=[C:14]([C:16]([NH2:18])=[O:17])[CH:15]=[C:7]([C:1]6[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=6)[CH:8]=5)[NH:12][CH:11]=4)[CH2:20][CH2:21]3)(=[O:37])=[O:36])[CH:31]=2)=[N:26]1

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 114271625-Phenyl-3-(4-piperidinyl)-1H-indole-7-carboxamideHCID 862321865-(3-Isoxazolyl)-3-thiophenesulfonyl chloride

Product 1

HCID 59003295HCID 59003295, compound

Procedure

Following the general procedure in example 267, 5-(phenyl)-3-(4-piperidinyl)-1H-indole-7-carboxamide (32 mg, 0.1 mmol), 5-(3-isoxazolyl)-3-thiophenesulfonyl chloride (37.5 mg, 0.15 mmol) and triethylamine (0.06 mL, 0.3 mmol) were reacted to form the desired product which was purified by Gilson HPLC (CH3CN/Water, 0.1% TFA) (11.7 mg, 22%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-3c8f89e87cc44f57aa2ea4a8b5146d30
Source dataset
uspto-grants-2010_12
Patent number
US07858796B2

Reaction notes

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