Triethylamine → HCID 59003348, compound

HRID 2267587Notes

Reaction equation

HRID 2267587 reaction equation
[C:1]1([C:7]2[CH:8]=[C:9]3[C:13](=[C:14]([C:16]([NH2:18])=[O:17])[CH:15]=2)[NH:12][CH:11]=[C:10]3[CH:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:25][C:26]1[S:27][C:28]([S:32](Cl)(=[O:34])=[O:33])=[C:29]([CH3:31])[N:30]=1.C(N(CC)CC)C>>[CH3:25][C:26]1[S:27][C:28]([S:32]([N:22]2[CH2:23][CH2:24][CH:19]([C:10]3[C:9]4[C:13](=[C:14]([C:16]([NH2:18])=[O:17])[CH:15]=[C:7]([C:1]5[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=5)[CH:8]=4)[NH:12][CH:11]=3)[CH2:20][CH2:21]2)(=[O:34])=[O:33])=[C:29]([CH3:31])[N:30]=1

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 2776248Dimethyl-1,3-thiazole-5-sulfonyl chlorideHCID 114271625-Phenyl-3-(4-piperidinyl)-1H-indole-7-carboxamide

Product 1

HCID 59003348HCID 59003348, compound

Procedure

Following the general procedure in example 267, 5-phenyl-3-(4-piperidinyl)-1H-indole-7-carboxamide (32 mg, 0.1 mmol), 2,4-dimethyl-1,3-thiazole-5-sulfonyl chloride (24.8 mg, 0.15 mmol) and triethylamine (0.06 mL, 0.3 mmol) were reacted to form the desired product which was purified by Gilson HPLC (CH3CN/Water, 0.1% TFA) (12.7 mg, 26%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-a7dcfc659d384a09a12b7236b23168b9
Source dataset
uspto-grants-2010_12
Patent number
US07858796B2

Reaction notes

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