Triethylamine → HCID 59003307, compound

HRID 2267589Notes

Reaction equation

HRID 2267589 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]2[C:15]3[C:10](=[C:11]([C:21]([NH2:23])=[O:22])[CH:12]=[C:13]([C:16]4[CH:20]=[CH:19][S:18][CH:17]=4)[CH:14]=3)[NH:9][CH:8]=2)[CH2:3][CH2:2]1.[CH3:24][N:25]1[CH:29]=[C:28]([S:30](Cl)(=[O:32])=[O:31])[N:27]=[CH:26]1.C(N(CC)CC)C>>[CH3:24][N:25]1[CH:29]=[C:28]([S:30]([N:1]2[CH2:6][CH2:5][CH:4]([C:7]3[C:15]4[C:10](=[C:11]([C:21]([NH2:23])=[O:22])[CH:12]=[C:13]([C:16]5[CH:20]=[CH:19][S:18][CH:17]=5)[CH:14]=4)[NH:9][CH:8]=3)[CH2:3][CH2:2]2)(=[O:32])=[O:31])[N:27]=[CH:26]1

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 27368871-methyl-1H-imidazole-4-sulfonyl chlorideHCID 596006643-(4-piperidinyl)-5-(3-thienyl)-1H-indole-7-carboxamide

Product 1

HCID 59003307HCID 59003307, compound

Procedure

Following the general procedure in example 267, 3-(4-piperidinyl)-5-(3-thienyl)-1H-indole-7-carboxamide (40 mg, 0.12 mmol), 1-methyl-1H-imidazole-4-sulfonyl chloride (29.7 mg, 0.18 mmol) and triethylamine (0.05 mL, 0.36 mmol) were reacted to form the desired product which was purified by Gilson HPLC (CH3CN/Water, 0.1% TFA) (20 mg, 34%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-1dc31337a80b406c9dc68dd6656e4f86
Source dataset
uspto-grants-2010_12
Patent number
US07858796B2

Reaction notes

Loading…