(R)-1,2-Epoxypropane → HCID 66841456, compound

HRID 2267905Notes

Reaction equation

HRID 2267905 reaction equation
[CH3:1][C@H:2]1[C@H:7]([O:8][C:9](=[O:14])[C:10]([CH3:13])([CH3:12])[CH3:11])[CH2:6][CH2:5][NH:4][CH2:3]1.[CH3:15][C@@H:16]1[CH2:18][O:17]1>C(O)C>[OH:17][C@H:16]([CH3:18])[CH2:15][N:4]1[CH2:5][CH2:6][C@@H:7]([O:8][C:9](=[O:14])[C:10]([CH3:13])([CH3:12])[CH3:11])[C@H:2]([CH3:1])[CH2:3]1

Participants

4

Reactant 2

HCID 146261(R)-1,2-EpoxypropaneHCID 59600263(3R,4R)-3-methylpiperidin-4-yl pivalate

Product 1

HCID 66841456HCID 66841456, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of piperidine 20 (3 g, 15.05 mmol) and (R)-2-methyl-oxirane (15.05 ml, 150.5 mmol) in 10 ml of ethanol is stirred for 24 hours in a closed flask. The solvent is evaporated and the residue distilled in a Kugelrohr apparatus (0.08 mbar, 80-90 C).

Workup

  1. customThe solvent is evaporated
  2. distillationthe residue distilled in a Kugelrohr apparatus (0.08 mbar, 80-90 C)

Sources & evidence

ORD record
ord-d37179dae5e44ed9b6bd8d0c2131dd92
Source dataset
uspto-grants-2010_12
Patent number
US07858781B2

Reaction notes

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