反应详情

128 (4.7 g, 17.6 mmol) and 1-benzyl-piperidin-4-ylamine (3.3 g, 17.6 mmol) are dissolved in DMF (70 ml) and after addition of TBTU (6.4 g, 19.4 mmol) and ethyldiisopropylamine (12 ml, 70.4 mmol) the mixture is stirred at room temperature for 2 h. Then the solvent is evaporated at high vacuum. The residue is dissolved in ethyl acetate washed with saturated aqueous sodium hydrogen carbonate and brine. The organic layers are dried over sodium sulfate and evaporated under reduced pressure. The crude mixture is crystallized from methanol.

1. customThen the solvent is evaporated at high vacuum
2. dissolutionThe residue is dissolved in ethyl acetate
3. washwashed with saturated aqueous sodium hydrogen carbonate and brine
4. dry with materialThe organic layers are dried over sodium sulfate
5. customevaporated under reduced pressure
6. customThe crude mixture is crystallized from methanol