Triethylamine → HCID 18349671, compound

HRID 2268273Notes

Reaction equation

HRID 2268273 reaction equation
Cl.[CH2:2]([O:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]([NH2:19])([CH3:18])[CH3:17])=[CH:12][CH:11]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[C:20](Cl)(=[O:23])[CH:21]=[CH2:22].C(N(CC)CC)C>ClCCl>[CH2:2]([O:9][C:10]1[CH:11]=[CH:12][C:13]([C:16]([NH:19][C:20](=[O:23])[CH:21]=[CH2:22])([CH3:17])[CH3:18])=[CH:14][CH:15]=1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 13140Acryloyl chlorideHCID 52988777HCID 52988777, compound

Product 1

HCID 18349671HCID 18349671, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1-(4-Benzyloxyphenyl)-1-methylethylamine hydrochloride (25.0 g) was treated with acryloyl chloride (8.43 ml) in dichloromethane (250 ml) containing triethylamine (14.4 ml) to give N-[1-(4-benzyloxyphenyl)-1-methylethyl]acrylamide, m.p. 116-117° C.

Sources & evidence

ORD record
ord-805909f30866455794390e1a6b71a1cd
Source dataset
uspto-grants-2001_12
Patent number
US06326500B1

Reaction notes

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