Sodium Bicarbonate → HCID 20709190, compound

HRID 2268428Notes

Reaction equation

HRID 2268428 reaction equation
CS[C:3]1[N:11]=[C:10]2[C:6]([N:7]=[CH:8][N:9]2[CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][O:13]2)=[C:5]([NH:18][CH2:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[N:4]=1.O[O:28][S:29]([O-:31])=O.[K+].[C:33](=O)([O-])O.[Na+]>>[CH3:33][S:29]([C:3]1[N:11]=[C:10]2[C:6]([N:7]=[CH:8][N:9]2[CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][O:13]2)=[C:5]([NH:18][CH2:19][CH2:20][C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[N:4]=1)(=[O:31])=[O:28]

Participants

4

Reactant 3

HCID 516892Sodium BicarbonateHCID 207091892-(Methylsulfanyl)-N-phenethyl-9-tetrahydro-2H-pyran-2-yl-9H-purin-6-amineHCID 23707502Potassium hydroxy sulfite

Product 1

HCID 20709190HCID 20709190, compoundYield 118.4%

Procedure

The title compound was prepared by a similar method to preparation 8 from 2-(methylsulfanyl)-N-phenethyl-9-tetrahydro-2H-pyran-2-yl-9H-purin-6-amine (16.7 g, 45 mmol) (preparation 42), Oxone (trade mark) (42.0 g, 136 mmol) and solid sodium hydrogen carbonate (20 g, 238 mmol). This gave the title compound (21.4 g) as a white solid. MS: 402 (MH+).

Sources & evidence

ORD record
ord-176d79a468384ac2908b75aeef046f00
Source dataset
uspto-grants-2001_12
Patent number
US06326359B1

Reaction notes

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