反应详情

To a solution of 2-(8-iodooctyl)-4,5,6,7-tetramethoxyindan (1.98 g) in DMF (10 ml) was dropwise added potassium phthalimide (924 mg). After being stirred at room temperature for 12 hr, the reaction mixture was diluted with ethyl acetate. The organic layer was washed with water and saturated aqueous sodium chloride and dried. The solvent was removed in vacuo and the residue was purified by alumina column chromatography (hexane to hexane:ethyl acetate=10:1) and then recrystallized from hexane gave the entitled compound (1.74 g) as crystals.

1. washThe organic layer was washed with water and saturated aqueous sodium chloride
2. customdried
3. customThe solvent was removed in vacuo
4. customthe residue was purified by alumina column chromatography (hexane to hexane:ethyl acetate=10:1)
5. customrecrystallized from hexane