反应详情

A mixture of 7-(2-iodoethyl)-1,2,3,4-tetramethoxy-6,7,8,9-tetrahydro-5H-benzo[a]cycloheptene (1.50 g), 2-hydroxypyridine (407 mg), and potassium carbonate (987 mg) in DMF (15 ml) was stirred at room temperature for 12 hr. The reaction mixture was diluted with water and extracted with ethyl acetate. The organic layer was washed with water and saturated aqueous sodium chloride and dried. The solvent was removed in vacuo. The residue was diluted with hexane and the resultant crystals were collected by filtration. The crystals were recrystallized from hexane-ethyl acetate to obtain 2-[2-(1,2,3,4-tetramethoxy-6,7,8,9-tetrahydro-5H-benzo[a]cyclohepten-7-yl)ethoxy]pyridine (830 mg).

1. extractionextracted with ethyl acetate
2. washThe organic layer was washed with water and saturated aqueous sodium chloride
3. customdried
4. customThe solvent was removed in vacuo
5. additionThe residue was diluted with hexane
6. filtrationthe resultant crystals were collected by filtration
7. customThe crystals were recrystallized from hexane-ethyl acetate