HCID 69948689, compound → HCID 18348847, compound

HRID 2268637Notes

Reaction equation

HRID 2268637 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].C(OC(=O)[N:14]([CH2:21][CH2:22][O:23][C:24]1[CH:29]=[C:28]([C:30](=[O:45])[N:31]([CH:40]2[CH2:44][CH2:43][CH2:42][CH2:41]2)[CH2:32][CH2:33][CH2:34][N:35]2[CH2:39][CH2:38][CH2:37][CH2:36]2)[CH:27]=[C:26]([Cl:46])[CH:25]=1)[C:15]1[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=1)(C)(C)C>ClCCl.FC(F)(F)C(O)=O>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[Cl:46][C:26]1[CH:27]=[C:28]([CH:29]=[C:24]([O:23][CH2:22][CH2:21][NH:14][C:15]2[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=2)[CH:25]=1)[C:30]([N:31]([CH:40]1[CH2:44][CH2:43][CH2:42][CH2:41]1)[CH2:32][CH2:33][CH2:34][N:35]1[CH2:39][CH2:38][CH2:37][CH2:36]1)=[O:45]

Participants

4

Reactant 1

HCID 69948689HCID 69948689, compound

Product 1

HCID 18348847HCID 18348847, compoundYield 183.8%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of (2-{3-chloro-5-[cyclopentyl-(3-pyrrolidin-1-yl-propyl)-carbamoyl]-phenoxy}-ethyl)-pyridin-4-yl-carbamic acid tert-butyl ester trifluoroacetate (0.080 g) in a mixture of dichloromethane (1 ml) and trifluoroacetic acid (1 ml) was stored at room temperature for 2 h and then concentrated under reduced pressure to give the title compound (0.075 g) as a colourless gum.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-f8da31327ad94f108e1de4cad5a2ba49
Source dataset
uspto-grants-2001_12
Patent number
US06326386B1

Reaction notes

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