HCID 18348884, compound → HCID 18348976, compound

HRID 2268639Notes

Reaction equation

HRID 2268639 reaction equation
C(OC([N:8]([C:33]1[CH:38]=[CH:37][N:36]=[CH:35][CH:34]=1)[CH2:9][CH2:10][O:11][C:12]1[CH:13]=[C:14]([CH:29]=[C:30]([Cl:32])[CH:31]=1)[C:15]([N:17]([CH:24]1[CH2:28][CH2:27][CH2:26][CH2:25]1)[CH2:18][CH2:19][CH2:20][C:21]([OH:23])=[O:22])=[O:16])=O)(C)(C)C>FC(F)(F)C(O)=O>[Cl:32][C:30]1[CH:29]=[C:14]([CH:13]=[C:12]([O:11][CH2:10][CH2:9][NH:8][C:33]2[CH:34]=[CH:35][N:36]=[CH:37][CH:38]=2)[CH:31]=1)[C:15]([N:17]([CH:24]1[CH2:25][CH2:26][CH2:27][CH2:28]1)[CH2:18][CH2:19][CH2:20][C:21]([OH:23])=[O:22])=[O:16]

Participants

3

Reactant 1

HCID 18348884HCID 18348884, compound

Product 1

HCID 18348976HCID 18348976, compoundYield 734.7%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of 4-({3-[2-(tert-butoxycarbonyl-pyridin-4-yl-amino)-ethoxy]-5-chloro-benzoyl}-cyclopentyl-amino)-butyric acid (0.015 g) in trifluoroacetic acid (3 ml) was stored at room temperature for 2 h and then the solvent removed under reduced pressure. The residue was purified by preparative hplc to give title compound (0.09 g) as a colourless gum.

Workup

  1. customthe solvent removed under reduced pressure
  2. customThe residue was purified by preparative hplc

Sources & evidence

ORD record
ord-4e02574ddec643e4b4c98c41ffefb927
Source dataset
uspto-grants-2001_12
Patent number
US06326386B1

Reaction notes

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