Trifluoroacetic acid → HCID 18349146, compound

HRID 2268666Notes

Reaction equation

HRID 2268666 reaction equation
C(OC(=O)[N:7]([CH2:14][CH2:15][O:16][C:17]1[CH:22]=[C:21]([C:23](=[O:41])[N:24]([CH:36]2[CH2:40][CH2:39][CH2:38][CH2:37]2)[CH2:25][CH2:26][CH2:27][NH:28][S:29]([C:32]([F:35])([F:34])[F:33])(=[O:31])=[O:30])[CH:20]=[C:19]([Cl:42])[CH:18]=1)[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1)(C)(C)C.[F:44][C:45]([F:50])([F:49])[C:46]([OH:48])=[O:47]>ClCCl>[F:44][C:45]([F:50])([F:49])[C:46]([OH:48])=[O:47].[Cl:42][C:19]1[CH:20]=[C:21]([CH:22]=[C:17]([O:16][CH2:15][CH2:14][NH:7][C:8]2[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=2)[CH:18]=1)[C:23]([N:24]([CH:36]1[CH2:40][CH2:39][CH2:38][CH2:37]1)[CH2:25][CH2:26][CH2:27][NH:28][S:29]([C:32]([F:33])([F:35])[F:34])(=[O:30])=[O:31])=[O:41]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 54163406HCID 54163406, compound

Product 1

HCID 18349146HCID 18349146, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of (2-{3-chloro-5-[cyclopentyl-(3-trifluoromethanesulfonylamino-propyl)-carbamoyl]-phenoxy}-ethyl)-pyridin-4-yl-carbamic acid tert-butyl ester (0.0118 g) in dichloromethane (1 ml) and trifluoroacetic acid (1 ml) was stored at room temperature for 19 h and then concentrated under reduced pressure. The title compound was obtained as a pale brown gum (0.010 g).

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-a8639c5bb4c6453e88004b2da8dfdc20
Source dataset
uspto-grants-2001_12
Patent number
US06326386B1

Reaction notes

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