Trifluoroacetic acid → HCID 18348945, compound

HRID 2268668Notes

Reaction equation

HRID 2268668 reaction equation
C(OC(=O)[N:7]([CH2:14][CH2:15][O:16][C:17]1[CH:22]=[C:21]([Cl:23])[CH:20]=[C:19]([C:24](=[O:37])[N:25]([CH2:29][CH2:30][C:31]2[O:35][N:34]=[C:33]([NH2:36])[N:32]=2)[CH:26]([CH3:28])[CH3:27])[CH:18]=1)[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1)(C)(C)C.[F:39][C:40]([F:45])([F:44])[C:41]([OH:43])=[O:42]>ClCCl>[F:39][C:40]([F:45])([F:44])[C:41]([OH:43])=[O:42].[NH2:36][C:33]1[N:32]=[C:31]([CH2:30][CH2:29][N:25]([CH:26]([CH3:28])[CH3:27])[C:24](=[O:37])[C:19]2[CH:18]=[C:17]([O:16][CH2:15][CH2:14][NH:7][C:8]3[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=3)[CH:22]=[C:21]([Cl:23])[CH:20]=2)[O:35][N:34]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 54289105HCID 54289105, compound

Product 1

HCID 18348945HCID 18348945, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of [2-(3-{[2-(3-amino[1,2,4]oxadiazol-5-yl)-ethyl]-isopropyl-carbamoyl}-5-chloro-phenoxy)-ethyl]-pyridin-4-yl-carbamic acid tert-butyl ester (0.064 g) in dichloromethane (1 ml) and trifluoroacetic acid (1 ml) was stored at room temperature for 5 h and then concentrated under reduced pressure. The residue was subjected to preparative hplc to give the title compound as a pale yellow foam (0.043 g).

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-e62ceb4e9d774e5d966a645f8b0c9749
Source dataset
uspto-grants-2001_12
Patent number
US06326386B1

Reaction notes

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