Trifluoroacetic acid → HCID 18348875, compound

HRID 2268671Notes

Reaction equation

HRID 2268671 reaction equation
C(OC(=O)[N:7]([CH2:14][CH2:15][O:16][C:17]1[CH:22]=[C:21]([C:23](=[O:35])[N:24]([CH:32]([CH3:34])[CH3:33])[CH2:25][CH2:26][N:27]2[CH:31]=[N:30][CH:29]=[N:28]2)[CH:20]=[C:19]([Cl:36])[CH:18]=1)[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1)(C)(C)C.[F:38][C:39]([F:44])([F:43])[C:40]([OH:42])=[O:41]>ClCCl>[F:38][C:39]([F:44])([F:43])[C:40]([OH:42])=[O:41].[Cl:36][C:19]1[CH:20]=[C:21]([CH:22]=[C:17]([O:16][CH2:15][CH2:14][NH:7][C:8]2[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=2)[CH:18]=1)[C:23]([N:24]([CH:32]([CH3:33])[CH3:34])[CH2:25][CH2:26][N:27]1[CH:31]=[N:30][CH:29]=[N:28]1)=[O:35]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 54198953HCID 54198953, compound

Product 1

HCID 18348875HCID 18348875, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of (2-{3-chloro-5-[isopropyl-(2-[1,2,4]triazol-1-yl-ethyl)-carbamoyl]-phenoxy}-ethyl)-pyridin-4-yl-carbamic acid tert-butyl ester (0.097 g) in dichloromethane (5 ml) was added trifluoroacetic acid (2 ml) and the mixture was stirred at room temperature for 3 h. The solvent was evaporated under reduced pressure and the residue subjected to preparative hplc to give the title compound (0.093 g) as a clear oil.

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-db63c30596384ae0a943611a1500e3e6
Source dataset
uspto-grants-2001_12
Patent number
US06326386B1

Reaction notes

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