Trifluoroacetic acid → HCID 18349164, compound

HRID 2268679Notes

Reaction equation

HRID 2268679 reaction equation
C(OC(=O)[N:7]([CH2:14][CH2:15][O:16][C:17]1[CH:22]=[C:21]([C:23](=[O:40])[N:24]([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[CH2:25][CH2:26][O:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][N:29]=2)[CH:20]=[C:19]([Cl:41])[CH:18]=1)[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1)(C)(C)C.[F:43][C:44]([F:49])([F:48])[C:45]([OH:47])=[O:46]>ClCCl>[F:43][C:44]([F:49])([F:48])[C:45]([OH:47])=[O:46].[F:43][C:44]([F:49])([F:48])[C:45]([OH:47])=[O:46].[Cl:41][C:19]1[CH:20]=[C:21]([CH:22]=[C:17]([O:16][CH2:15][CH2:14][NH:7][C:8]2[CH:9]=[CH:10][N:11]=[CH:12][CH:13]=2)[CH:18]=1)[C:23]([N:24]([C:34]1[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=1)[CH2:25][CH2:26][O:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][N:29]=1)=[O:40]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69949759HCID 69949759, compound

Product 1

HCID 18349164HCID 18349164, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of {2-[3-chloro-5-(phenyl-2-(pyridin-2-yloxy)-ethyl-carbamoyl)-phenoxy]-ethyl}-pyridin-4-yl-carbamic acid tert-butyl ester (0.065 g) and trifluoroacetic acid (0.75 ml) in dichloromethane (0.75 ml) was stirred at room temperature for 2 h then concentrated under vacuum, co-evaporating with dichloromethane to give the title compound as a yellow oil (0.086 g).

Workup

  1. concentrationthen concentrated under vacuum, co-evaporating with dichloromethane

Sources & evidence

ORD record
ord-be0cc362416d45cab7f8c1e5f2600cdd
Source dataset
uspto-grants-2001_12
Patent number
US06326386B1

Reaction notes

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