Trifluoroacetic acid → HCID 18348872, compound

HRID 2268686Notes

Reaction equation

HRID 2268686 reaction equation
C(OC(=O)[N:7]([CH2:14][CH2:15][O:16][C:17]1[CH:22]=[C:21]([C:23](=[O:34])[N:24]([CH:31]([CH3:33])[CH3:32])[CH2:25][CH2:26][S:27](=[O:30])(=[O:29])[NH2:28])[CH:20]=[C:19]([Cl:35])[CH:18]=1)[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1)(C)(C)C.[F:37][C:38]([F:43])([F:42])[C:39]([OH:41])=[O:40]>ClCCl>[F:37][C:38]([F:43])([F:42])[C:39]([OH:41])=[O:40].[Cl:35][C:19]1[CH:20]=[C:21]([CH:22]=[C:17]([O:16][CH2:15][CH2:14][NH:7][C:8]2[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=2)[CH:18]=1)[C:23]([N:24]([CH:31]([CH3:33])[CH3:32])[CH2:25][CH2:26][S:27](=[O:30])(=[O:29])[NH2:28])=[O:34]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69949518HCID 69949518, compound

Product 1

HCID 18348872HCID 18348872, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of (2-{3-chloro-5-[isopropyl-(2-sulfamoyl-ethyl)-carbamoyl]-phenoxy}-ethyl)-pyridin-4-yl-carbamic acid tert-butyl ester (0.012 g) in a mixture of dichloromethane (1 ml) and trifluoroacetic acid (1 ml) was stored at room temperature for 64 h and then concentrated under reduced pressure to give the title compound (0.011 g) as a colourless gum.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-d178157feb234444a0d9233125df7dd5
Source dataset
uspto-grants-2001_12
Patent number
US06326386B1

Reaction notes

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