反应详情

N-Ethyl 3-benzyloxycarbonylamino-1-propanol t-butyldimethylsilyl ether (8.5 g) was dissolved in THF (120 ml), and to the resulting solution was added under ice-cooling a solution of 1N tetra-butylammonium fluoride in THF (48 ml). The resultant mixture was stirred at room temperature for 1 hour. Ethyl acetate and water were added to the reaction solution obtained. The organic layer so sepasated was washed with water and then dried over magnesium sulfate. The solvent was evaporated off from the solution, and the residue was purified by a silica gel chromatography, thus affording the titled compound (4.0 g; 71%)

1. additionto the resulting solution was added under ice-
2. customobtained
3. washThe organic layer so sepasated was washed with water
4. dry with materialdried over magnesium sulfate
5. customThe solvent was evaporated off from the solution
6. customthe residue was purified by a silica gel chromatography