反应详情

N-Ethyl 3-benzyloxycarbonylamino-1-propanol (4.0 g) was dissolved in methylene chloride (20 ml), and to the resulting solution were added pyridine (1.8 ml) and tosyl chloride (3.9 g). The resultant mixture was stirred at room temperature for 2 days. Ethyl acetate and water were added to the reaction solution obtained. The organic layer so separated was washed with an aqueous potassium hydrogen sulfate solution and then with water and then dried over magnesium sulfate. The solvent was evaporated off from the solution, and the residue was purified by a silica gel chromatography, thus affording the titled compound (4.4 g; 69%).

1. customobtained
2. customThe organic layer so separated
3. washwas washed with an aqueous potassium hydrogen sulfate solution
4. dry with materialwith water and then dried over magnesium sulfate
5. customThe solvent was evaporated off from the solution
6. customthe residue was purified by a silica gel chromatography