反应详情

N-Ethyl 3-benzyloxycarbonylamino-1-tosyloxypropane (1.02 g) was dissolved in acetone (20 ml), and to the resulting solution was added sodium iodide (0.80 g). The resultant mixture was stirred at 45° C. for 2 hours. Ethyl acetate and water were added to the reaction solution obtained, and the organic layer so separated was washed with water and then dried over magnesiumsulfate. The solvent was evaporated off from the solution, and the residue was purified by a silica gel chromatography, thus to afford the titled compound (0.69 g; 76%).

1. customobtained
2. customthe organic layer so separated
3. washwas washed with water
4. dry with materialdried over magnesiumsulfate
5. customThe solvent was evaporated off from the solution
6. customthe residue was purified by a silica gel chromatography