Sodium hydride → HCID 18332460, compound

HRID 2268937Notes

Reaction equation

HRID 2268937 reaction equation
Cl[C:2]1[C:11]2[C:6](=[C:7]([CH2:14][C:15]3[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=3)[C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[CH:5]=[N:4][N:3]=1.[Cl:21][C:22]1[CH:23]=[N:24][CH:25]=[C:26]([Cl:29])[C:27]=1[CH3:28].[H-].[Na+]>CN(C=O)C>[Cl:21][C:22]1[CH:23]=[N:24][CH:25]=[C:26]([Cl:29])[C:27]=1[CH2:28][C:2]1[C:11]2[C:6](=[C:7]([CH2:14][C:15]3[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=3)[C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[CH:5]=[N:4][N:3]=1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 109538273,5-Dichloro-4-methylpyridineHCID 18332456HCID 18332456, compound

Product 1

HCID 18332460HCID 18332460, compoundYield 41.4%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Operating analogously to what described in example 15 starting from 1-chloro-6-methoxy-5-pyridin-4-ylmethyl-phthalazine (1.38 g, 4.66 mmoles), prepared as described in example 142, 3,5-dichloro-4-methylpyridine (1.887 mg, 11.65 mmoles), DMF (20 ml), NaH (466 mg, 11.65 mmoles), 793 mg of the title compound were obtained.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-0c65baf9de5448e0a65c6ec79b973f45
Source dataset
uspto-grants-2001_12
Patent number
US06329370B1

Reaction notes

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