Dimethylformamide → 6-Methyl-2H-1,3-benzodioxole-5-carbaldehyde

HRID 2268992Notes

Reaction equation

HRID 2268992 reaction equation
CN([CH:4]=[O:5])C.P(Cl)(Cl)(Cl)=O.[CH2:11]1[O:19][C:18]2[CH:17]=[CH:16][C:15]([CH3:20])=[CH:14][C:13]=2[O:12]1>>[CH3:20][C:15]1[CH:14]=[C:13]2[O:12][CH2:11][O:19][C:18]2=[CH:17][C:16]=1[CH:4]=[O:5]

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 24813Phosphorus oxychlorideHCID 815641,3-Benzodioxole, 5-methyl-

Product 1

HCID 31462426-Methyl-2H-1,3-benzodioxole-5-carbaldehydeYield 11%

Conditions

Temperature
0 °C

Procedure

To DMF (6.5 ml, 83 mmoles) at 0° C. was added phosphorus oxychloride (3.9 ml, 42 mmoles). The solution was stirred 15 minutes at 0° C. followed by the addition of 3,4-(methylenedioxy)toluene (1.0 ml, 8.3 mmoles). The solution was heated to 110° C. upon which it became dark brown. 1.5 hours later the thick dark brown mixture was cooled to ambient temperature then added to ice (100 ml), and extracted with ether (100 ml). The organic layer was dried (MgSO4), filtered and concentrated. Flash chromatography (5% EtOAc/hexanes) provided 0.15 g (11%) of the title compound as a colorless oil.

Workup

  1. temperatureThe solution was heated to 110° C. upon which it
  2. temperature1.5 hours later the thick dark brown mixture was cooled to ambient temperature
  3. extractionextracted with ether (100 ml)
  4. dry with materialThe organic layer was dried (MgSO4)
  5. filtrationfiltered
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-a38e6c9b1581427fab0b7702128fe73d
Source dataset
uspto-grants-2001_12
Patent number
US06329387B2

Reaction notes

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