Ammonia → HCID 178494228, compound

HRID 2269018Notes

Reaction equation

HRID 2269018 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH3:12])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([O:20]C)[N:6]2[CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.N>Cl>[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH3:12])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([OH:20])[N:6]2[CH2:13][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 11098103HCID 11098103, compound

Product 1

HCID 178494228HCID 178494228, compoundYield 75.3%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

6-Amino-9-benzyl-2,8-dimethoxypurine (53 mg, 0.186 mmol) in concentrated hydrochloric acid (10 ml) was stirred for 3 hours at room temperature. The reaction mixture was made basic with 28% aqueous ammonia, and the resulting crystals were filtered and washed with water to give the subject compound (38 mg, yield 75%).

Workup

  1. filtrationthe resulting crystals were filtered
  2. washwashed with water

Sources & evidence

ORD record
ord-e61945571e634f72ad131f99685d4f4b
Source dataset
uspto-grants-2001_12
Patent number
US06329381B1

Reaction notes

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