Ammonia → HCID 178467447, compound

HRID 2269019Notes

Reaction equation

HRID 2269019 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH3:13])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([O:21]C)[N:6]2[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.N>Cl>[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH3:13])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([OH:21])[N:6]2[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 11130326HCID 11130326, compound

Product 1

HCID 178467447HCID 178467447, compoundYield 64.3%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

6-Amino-9-benzyl-2-ethoxy-8-methoxypurine (18 mg, 0.06 mmol) in concentrated hydrochloric acid (5 ml) was stirred for 3 hours at room temperature. The reaction mixture was made basic with 28% aqueous ammonia, and the resulting crystals were filtered and washed with water to give the subject compound (11 mg, yield 64%).

Workup

  1. filtrationthe resulting crystals were filtered
  2. washwashed with water

Sources & evidence

ORD record
ord-fb05f4a79bd14d80bcdc4d5fa52a7ad3
Source dataset
uspto-grants-2001_12
Patent number
US06329381B1

Reaction notes

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