Methanol → HCID 178483059, compound

HRID 2269025Notes

Reaction equation

HRID 2269025 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]([N:11]([CH3:13])[CH3:12])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5](Br)[N:6]2[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.C[OH:23]>Cl>[NH2:1][C:2]1[N:10]=[C:9]([N:11]([CH3:13])[CH3:12])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([OH:23])[N:6]2[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 887MethanolHCID 18332715HCID 18332715, compound

Product 1

HCID 178483059HCID 178483059, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

6-Amino-9-benzyl-2-dimethylamino-8-bromopurine (51 mg, 0.15 mmol) in concentrated hydrochloric acid (30 ml) and methanol (10 ml) were refluxed for 5 hours under heating. After removal of methanol, the reaction mixture was made basic with 28% aqueous ammonia. The resulting crystals were filtered, washed with water and dried to give the subject compound (38 mg, yield 91%).

Workup

  1. temperatureunder heating
  2. customAfter removal of methanol
  3. filtrationThe resulting crystals were filtered
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-a143d235141142de8f91d9cb9763585f
Source dataset
uspto-grants-2001_12
Patent number
US06329381B1

Reaction notes

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